Mixed allele malaria vaccines: Host protection and within-host selection
نویسندگان
چکیده
منابع مشابه
Within-Host Speciation of Malaria Parasites
BACKGROUND Sympatric speciation-the divergence of populations into new species in absence of geographic barriers to hybridization-is the most debated mode of diversification of life forms. Parasitic organisms are prominent models for sympatric speciation, because they may colonise new hosts within the same geographic area and diverge through host specialization. However, it has been argued that...
متن کاملAn Age-Structured Within-Host Model for Multistrain Malaria Infections
In this paper we propose an age-structured malaria within-host model taking into account multi-strains interaction. We provide a global analysis of the model depending upon some threshold T0. When T0 ≤ 1, then the disease free equilibrium is globally asymptotically stable and the parasites are cleared. On the contrary if T0 > 1, the model exhibits the competition exclusion principle. Roughly sp...
متن کاملThe within-host dynamics of malaria infection with immune response.
Malaria infection is one of the most serious global health problems of our time. In this article the blood-stage dynamics of malaria in an infected host are studied by incorporating red blood cells, malaria parasitemia and immune effectors into a mathematical model with nonlinear bounded Michaelis-Menten-Monod functions describing how immune cells interact with infected red blood cells and mero...
متن کاملMalaria Sporozoites Traverse Host Cells within Transient Vacuoles.
Plasmodium sporozoites are deposited in the host skin by Anopheles mosquitoes. The parasites migrate from the dermis to the liver, where they invade hepatocytes through a moving junction (MJ) to form a replicative parasitophorous vacuole (PV). Malaria sporozoites need to traverse cells during progression through host tissues, a process requiring parasite perforin-like protein 1 (PLP1). We find ...
متن کاملCenter manifold analysis and Hopf bifurcation of within-host virus model
A mathematical model of a within-host viral infection is presented. A local stability analysis of the model is conducted in two ways. At first, the basic reproduction number of the system is calculated. It is shown that when the reproduction number falls below unity, the disease free equilibrium (DFE) is globally asymptotically stable, and when it exceeds unity, the DFE is unstable and there ex...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Vaccine
سال: 2008
ISSN: 0264-410X
DOI: 10.1016/j.vaccine.2008.09.004